Kinda sad that credits won’t cross over still.

2021.10.16 21:09 Iarethedumbest Kinda sad that credits won’t cross over still.

I’m sitting in 150Mil in FH4. I’m never playing that game again when FH5 comes out so technically those are credits going to waste.
submitted by Iarethedumbest to ForzaHorizon [link] [comments]

2021.10.16 21:09 Penguinmaster118 The prophecy is true

The prophecy is true submitted by Penguinmaster118 to PewdiepieSubmissions [link] [comments]

2021.10.16 21:09 Trouse Test

Test submitted by Trouse to GMEJungle [link] [comments]

2021.10.16 21:09 PotatoInevitable7301 Flandre old laboratory inspired by baldi old laboratory chapter 1

Flandre old laboratory inspired by baldi old laboratory chapter 1 submitted by PotatoInevitable7301 to TECHNOTEDMODERN [link] [comments]

2021.10.16 21:09 SelfAwareMachine Are anticholinergic medications behind the growth of dementia and alzheimers epidemiology?

Anticholinergic drugs are among the most widely prescribed class of drugs today, used in the treatment of conditions from motion sickness to psychosis. Of the two 200 most prescribed drugs, a significant portion of them are Anticholinergic. I have limited the following studies to within the last two years, honestly because it was too depressing to dig any deeper.
Do Anticholinergic drugs cause dementia?:
Anticholinergic Drug Exposure and the Risk of DementiaA Nested Case-Control Study

There were significant increases in dementia risk for the anticholinergic antidepressants (adjusted OR [AOR], 1.29; 95% CI, 1.24-1.34), antiparkinson drugs (AOR, 1.52; 95% CI, 1.16-2.00), antipsychotics (AOR, 1.70; 95% CI, 1.53-1.90), bladder antimuscarinic drugs (AOR, 1.65; 95% CI, 1.56-1.75), and antiepileptic drugs (AOR, 1.39; 95% CI, 1.22-1.57) all for more than 1095 TSDDs.
Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis
Anticholinergic use for ≥3 months increased the risk of dementia on average by an estimated 46% versus nonuse. This relationship was consistent in studies assessing overactive bladder medications. The risk of developing dementia should be carefully considered in the context of potential benefit before prescribing anticholinergics.
Dose response relationship of cumulative anticholinergic exposure with incident dementia: validation study of Korean anticholinergic burden scale
This study confirmed the dose response relationship for cumulative anticholinergic burden measured using the Korean specific anticholinergic burden scale with incident dementia.
Anticholinergic drugs and the risk of dementia: A systematic review and meta-analysis
After pooling fourteen longitudinal and case-control studies with a total of 1,564,181 subjects, anticholinergic drug use was associated with an increased risk of all-cause dementia and Alzheimer's disease. Both low and high anticholinergic drug burdens were associated with dementia. Moreover, there was a dose-dependent relationship between anticholinergic drugs and risk of dementia. With respect to the categories of anticholinergic drugs, antiparkinson, urological drugs, and antidepressants increased the risk for dementia; however, cardiovascular and gastrointestinal drugs played potentially protective roles.
Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: a meta-analysis
Anticholinergic drug use, particularly long-term use, is associated with greater incidence of dementia and cognitive decline.
Anticholinergic medications and risk of dementia in older adults: Where are we now?
The review demonstrates moderate to strong risk of dementia with anticholinergic use in multiple studies involving older adults, irrespective of the study design, analytical approach, anticholinergic exposure and outcome definition. This risk is particularly significant with the cumulative burden and high-level anticholinergics. There also exists a dose-response relationship between anticholinergic use and increased risk for dementia. Therefore, anticholinergic agents can be considered as a modifiable risk factor for dementia and cognitive decline in older adults.
Are anticholinergics harmful to individuals with the conditions they are prescribed for?
Twenty-year effects of antipsychotics in schizophrenia and affective psychotic disorders
Participants with schizophrenia not on antipsychotics after the first 2 years have better outcomes than participants prescribed antipsychotics. Even when the confound by indication for prescribing antipsychotic medication is controlled for, participants with schizophrenia and affective psychosis do better than their medicated cohorts, strongly confirming the importance of exposing the role of aiDSP and antipsychotic drug resistance.
Five-Year Cumulative Exposure to Antipsychotic Medication After First-Episode Psychosis and its Association With 19-Year Outcomes
After adjustment for confounders, moderate and high cumulative exposure to antipsychotics within the first 5 years from FEP was consistently associated with a higher risk of adverse outcomes during the 19-year follow-up, as compared to low or zero exposure.
Cognitive burden of anticholinergic medications in psychotic disorders
Anticholinergic burden aggregated across all medications was inversely related to cognitive performance starting at ADS scores of 4 in participants with schizophrenia.
Long-term antipsychotic use and cognitive decline in community-dwelling older adults with mild–moderate Alzheimer disease: Data from NILVAD
Long-term antipsychotic use was associated with greater cognitive decline and dementia progression in community-dwelling older adults with mild–moderate AD.
Anticholinergic Medication Burden–Associated Cognitive Impairment in Schizophrenia
Anticholinergic medication burden in schizophrenia is substantial, common, conferred by multiple medication classes, and associated with cognitive impairments across all cognitive domains. Anticholinergic medication burden from all medication classes–including psychotropics used in usual care–should be considered in treatment decisions and accounted for in studies of cognitive functioning in schizophrenia.
The Impact of Anticholinergic Burden on Functional Capacity in Persons With Schizophrenia Across the Adult Life Span
In conclusion, people with schizophrenia are exposed to severe ACB that can have a direct negative impact on functional capacity after controlling for its impact on cognition. Reducing ACB could improve functional capacity and potentially real-world function in schizophrenia.
The effect of anticholinergic burden on cognitive and daily living functions in patients with schizophrenia
Our analysis shows that anticholinergic burden reduces cognitive and daily living functions in patients with schizophrenia. A drug strategy with minimal anticholinergic burden may be helpful to patients if it does not adversely affect clinical symptoms.
Anticholinergic Burden Measures Predict Older People's Physical Function and Quality of Life: A Systematic Review
The evidence supports association between increased ACB and future impairments in physical function and quality of life.
Consistency between anticholinergic burden scales in the elderly with fractures
The ACB scale identified the highest anticholinergic burden (26.8%) in prescriptions made the month before the fracture, and the highest agreement was between ACB and ADS (0.717); during hospitalization and at discharge, the cholinergic antagonists were best identified with ADS (77.7% and 72.1%, respectively), with the best agreement between ACB and ARS (0.613 and 0.568, respectively). The prescription of tramadol was found in 64.1% of hospitalized patients and in 61.4% of patients at the time of discharge.
Adverse Effects of Anticholinergic Drugs on Cognition and Mobility: Cutoff for Impairment in a Cross-Sectional Study in Young-Old and Old-Old Adults
Drugs with anticholinergic (antimuscarinic) properties are associated with cognitive impairment in individuals as young as 55 years, and only one such drug per day, regardless of its anticholinergic burden, is associated with both impaired cognition and impaired mobility in old-old adults. Therefore, wherever possible, clinicians should avoid prescribing drugs with anticholinergic properties.
A meta-analysis of observational studies on anticholinergic burden and fracture risk: evaluation of conventional burden scales
This result suggests that the relationship between anticholinergic drug burden and fracture risk may differ depending on the anticholinergic burden scale used.
Anticholinergics May Carry Significant Cognitive and Gait Burden in Parkinson's Disease
Patients with PD are exposed to significant anticholinergic burden from drugs prescribed for PD and non-PD indications. Higher anticholinergic burden is associated with cognitive impairment and FOG even in younger patients with PD.
Association between Anticholinergic Medication Use and Risk of Dementia among Patients with Parkinson's Disease
Among patients with Parkinson's disease in Taiwan, those with a high cumulative dose of anticholinergics had an increased risk of being diagnosed with dementia. Physicians should consider prescribing the lowest therapeutic dose of anticholinergic medication when making treatment decisions for patients with Parkinson's disease.
Do anticholinergics cause delirium and increase mortality?: Effect of anticholinergic burden on treatment modification, delirium and mortality in newly diagnosed dementia patients starting a cholinesterase inhibitor: A population-based study
This study showed that high anticholinergic burden negatively affected the treatment response to cholinesterase inhibitors and that an average ACB score />/3 was an independent prognostic factor for delirium or mortality in dementia patients.
Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
The strongest association of low heart rate variability was noted among patients on antipsychotic treatment with high-affinity muscarinic antagonism (i.e., clozapine, olanzapine and quetiapine).
Are doctors more wary about anticholinergics now that the risk of dementia is understood?:
Increasing prevalence of anticholinergic medication use in older people in England over 20 years: cognitive function and ageing study I and II
Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Use of potent anticholinergic medications nearly doubled in England's older population over 20 years with some of the greatest increases amongst those particularly vulnerable to anticholinergic side-effects.
Increase in anticholinergic burden from 1990 to 2015: Age-period-cohort analysis in UK biobank
Anticholinergic burden in the sample increased up to 9-fold over 25 years and was observed for both period and age effects across most classes of drugs. The greatest increase was seen in the prescribing of antidepressants. Female sex, lower education and greater deprivation were associated with greater anticholinergic burden.
Are medical professionals aware of the risk of anticholinergic drugs?:
Staff Awareness of Anti-Cholinergic Burden (ACB) - A Qualitative Cross-Sectional Study in a Tertiary Care Hospital
A total of 74% participants admitted to have no understanding of the term ACB, 48% participants prescribe anticholinergics in their daily role, 44% knew that cognition was adversely affected by anticholinergics, and 16% participants were aware of scoring system. Only 16% participants routinely counsel women of cognitive side effects when anticholinergics are started. 86% reported that they would avoid prescribing medications which might affect cognition if possible. If given choice as a patient, 94% would avoid these medications if they were informed of the specific side effects like impaired cognition, physical decline, falls, hospital admissions and increased mortality.
Are anticholinergic prescriptions being adequately screened for interactions?:
Polypharmacy among older adults with dementia compared with those without dementia in the United States
In a representative sample of outpatient visits, polypharmacy was extremely common among PWD, driven by a wide array of medication categories.
Inappropriate medication prescriptions are associated with impaired physical function across longitudinal and cross-sectional studies in older adults situated in diverse settings.
An overview of prevalence, determinants and health outcomes of polypharmacy
Our review showed that the prevalence of polypharmacy varied between 10% to as high as around 90% in different populations. Chronic conditions, demographics, socioeconomics and self-assessed health factors were independent predictors of polypharmacy. Polypharmacy was reported to be associated with various adverse outcomes after adjusting for health conditions.
Is there a consistent way to determine risk from Anticholinergic drugs?
Consistency between anticholinergic burden scales in the elderly with fractures
The scales evaluated show marked discrepancies between them, with highly variable frequencies of anticholinergic drugs identified at the different prescription times, and with low agreement among them, which is why the scales are not interchangeable in patients with bone fractures.
Anticholinergic Drug Burden and Delirium: A Systematic Review
ADB assessed with the ARS is consistently associated with delirium.
Are Anticholinergic drugs effective treatments?:
Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study
The 20-year data indicate that, longitudinally, after the first few years, antipsychotic medications do not eliminate or reduce the frequency of psychosis in schizophrenia, or reduce the severity of post-acute psychosis, although it is difficult to reach unambiguous conclusions about the efficacy of treatment in purely naturalistic or observational research. Longitudinally, on the basis of their psychotic activity and the disruption of functioning, the condition of the majority of SZ prescribed antipsychotics for multiple years would raise questions as to how many of them are truly in remission.
submitted by SelfAwareMachine to neuro [link] [comments]

2021.10.16 21:09 StardustAstronaut Too many carbs the first day.

I had 88g of carbs so far and it’s 3pm. I must have had too much sugar in my coffee when I normally have 3 table spoons, I will try to cut down to 1. Same with creamer as that’s 9 grams also. I really need to watch out for sneaky carbs.
I’m new to keto but second time trying for it. Got some meal prep ideas to keep me going. But how do I stay under 50 grams? It felt easier the first time.
submitted by StardustAstronaut to keto [link] [comments]

2021.10.16 21:09 interstingpost I FINALLY GOT HIM

I FINALLY GOT HIM submitted by interstingpost to CookieRunKingdoms [link] [comments]

2021.10.16 21:09 Flash-3_ FT - looking for rune offer

FT - looking for rune offer submitted by Flash-3_ to Diablo2XboxTrading [link] [comments]

2021.10.16 21:09 Neala4aq but...but....why though 😩 / i will upvote everyone back :)

but...but....why though 😩 / i will upvote everyone back :) submitted by Neala4aq to OurDogsLove [link] [comments]

2021.10.16 21:09 First-Cold1219 Tobias Rahim

Okay, helt ærligt. Hvor mange af jer, har som mig, forsøgt at Google sig frem til Tobias Rahims nøgenbillede? Hånden op ✋
submitted by First-Cold1219 to InfluencergossipDK [link] [comments]

2021.10.16 21:09 magneticfarce I broke 100 today!

submitted by magneticfarce to golf [link] [comments]

2021.10.16 21:09 Moppe13 Im tierd of how racist people are to people from China

Yeah i know the Chinese politics might not be as good as the europeans have but do people really have to critize everything? And im so goddamn tierd of the discussion about if Taiwan is a country or not. I just want to live as a normal person withou getting alot of racist comments and questions.
submitted by Moppe13 to teenagers [link] [comments]

2021.10.16 21:09 Louis-Toadvine S05E13 Easter Egg

Leary Bros. The actor that plays Derans' dad is called Denis Leary. Thought this was really cool.
submitted by Louis-Toadvine to animalkingdom [link] [comments]

2021.10.16 21:09 Gilles_from_Paris NINA HAGEN - PUNKWEDDING [punk rock] (1988) from French TV show "Lahaye d'honneur"

NINA HAGEN - PUNKWEDDING [punk rock] (1988) from French TV show submitted by Gilles_from_Paris to Nina_Hagen [link] [comments]

2021.10.16 21:09 AngeloC1 UnitePro Draft Simulator - A Pokémon UNITE draft for your tournaments

UnitePro Draft Simulator - A Pokémon UNITE draft for your tournaments Hi Pokémon Trainer, a new UnitePro tool is finally here: UnitePro Draft Simulator
Draft Mode In Pokemon Unite Hey there Trainer, welcome to UnitePro. So you are interested in Draft and ban simulator for Pokémon UNITE? Let's dive right in!
Team Names (Coming soon) In order to make the Draft as fair as possible, you can input two team names. These team names will be randomly outputted into Team A or Team B to prevent any form of bias.
Ban Counter We have several options available at the top for all your Draft simulating needs. For example, you can use the Ban counter to select how many bans you want each team to be able to make. For example, if you only want to allow teams to have 1 ban each, set it to 1. It can go from 0 to 5. If you are a tournament organizer, be aware that more bans means less pokémons to play from so your participants must have unlocked the necessary amount of pokémons. Note: This is only allowed to be changed before the first pokémon is selected. Once a pick/ban has been made, you can no longer change this. You must reload the page if you wish to change.
Unique Only This toggle allows you to choose whether players on opposing teams are allowed to pick the same pokémon. For example, is both teams allowed to have Blissey? If you are a tournament organizer, please be aware Unique only drafts means the participants should have at minimum 10 pokémons, not including bans, unlocked to be safely able to play. Note: This is only allowed to be toggled before the first pokémon is selected. Once a pick/ban has been made, you can no longer toggle this. You must reload the page if you wish to change.
Timed Draft You an also enable the Timed Draft mode. When you click Start, the timer a countdown will begin for 60 seconds. Whenever a pokémon is selected, the timer will reset to 60 seconds. When there are less than 10 seconds remaining, the color will change to red. If no pokémons have been banned/selected within the allotted time, a random pokémon will be chosen for you. When drafting, synergy and counters are extremely important factors in deciding who will have an advantage when playing the game.
Solo (Bot AI Mode) If you simply want to practice drafting, you can enable the Bot AI we have implemented. It is super duper smart, almost as smart as Misty's Psyduck.
submitted by AngeloC1 to PokemonUnite [link] [comments]

2021.10.16 21:09 cytsunny May I have a referral code for opening new Paypal account?

I am going to open a new Paypal account. Whoever reply a referral code below first and I will use that code for regeistering. (I am also asking elsewhere, e.g. in chat, so don't be surprised if the first replied code is not used)
submitted by cytsunny to beermoneyuk [link] [comments]

2021.10.16 21:09 endisnearhere I’ve squished about 10 of these in the last 24 hours in two different sinks, and a desk in another room. Baby roaches?

submitted by endisnearhere to pestcontrol [link] [comments]

2021.10.16 21:09 DragonSalvation A list of all “wing” like gliders that you wear on your back like the Hunters skyblade/Wing span?

Does anyone have a list? I’m trying to get a list of all the gliders that act as wings. Ones that you don’t hold with your hands. The ones that actually go on your back similarly to “Wingspan”. Thank you!
submitted by DragonSalvation to FortniteCosmetics [link] [comments]

2021.10.16 21:09 flipzone CORSAIR Sabre RGB PRO Champion Series FPS/MOBA Gaming Mouse $59.99 (lowest)

submitted by flipzone to amazoncanadadeals [link] [comments]

2021.10.16 21:09 vskhosa Can I transfer DCPP to RRSP?

I have a DCPP from my previous employer sitting in Sunlife. I called them to ask about transfer procedure to RRSP. They said that I have to transfer it to LIRA. I know from other Reddit discussions that many people have transferred their DCPP to RRSP.
Now my question is, what determines if a DCPP can or cannot be transferred to RRSP? I heard it could be a provincial thing or amount of money but I am not sure. My DCPP has just over 20K in it and I am in Ontario.
submitted by vskhosa to PersonalFinanceCanada [link] [comments]

2021.10.16 21:09 Z0MBI3K1D does anyone know what my gender identity would be called?

hello! i've been struggling with my gender for the last few years and i was wondering if others had an idea what this would be called. i already know that i'm nonbinary, i just don't know what label underneath that umbrella i'm comfortable with! i just want to know so it's easier to explain to others. :D
for me, i feel as if i'm gender neutral, but not in a "genderless" way. i feel like any gender, any pronoun, and any descriptor could apply to me- but i get upset if someone only uses one type for me consistently. i tend to go through phases of being particularly attached to being feminine or masculine, and wanting to be seen/referred to that way, but not actually being male/female or aligned with them. i've heard of being all genders, but i don't know if that fits me either? i don't feel like i'm ANY gender, i just feel like i'm neutral towards any and fine being referred to as male/female/other.
so, does anyone know any similar label to that i could use
submitted by Z0MBI3K1D to lgbt [link] [comments]

2021.10.16 21:09 maponpon Need expert eyes to help me determine whether my opals are real or synthetic. What do you think? (bought in Greece this summer)

Need expert eyes to help me determine whether my opals are real or synthetic. What do you think? (bought in Greece this summer) submitted by maponpon to whatsthisrock [link] [comments]

2021.10.16 21:09 DavidPT008 Goverment takeover and trip wires is so good wth, 1 airstrike and everything in that area disapears, they never build strength. Also private contractors is very good, basicaly keep your coalition soldiers forever at a quite low cost

Goverment takeover and trip wires is so good wth, 1 airstrike and everything in that area disapears, they never build strength. Also private contractors is very good, basicaly keep your coalition soldiers forever at a quite low cost submitted by DavidPT008 to rebelinc [link] [comments]

2021.10.16 21:09 Objective-Style-9864 Client Remote Access ISO 27001 compatibel

Hi msp! We are a small MSP which is fast growing. Right now we are building a new infrastructure for our Core Services(AD, Files, Passwords). Probably in the future we want to get ISO 27001. I don't no much about 27001 but i know that it needs extensive logging. We are using Devolutions Remote Desktop Manager and Password Server. How do you guys build remote access to your clients so your technician can always simply access Client infrastructures? Everything needs to be accountable and traceable. => Support DMZ with S2S and BiNAT to Clients? Probably also something like Cyberark for PAM and restrictions.
submitted by Objective-Style-9864 to msp [link] [comments]

2021.10.16 21:09 MTFMagno need a group anyone interested in having a new member that plays daily

submitted by MTFMagno to GroupIronman [link] [comments]